OPPTS 870.7600: Dermal penetration
In Vitro Metabolism
- Induction | Inhibition | Reaction Phenotyping
- Metabolic Stability
- Transporter Interactions & DDIs
- Protein Binding (PBB; plasma, etc.)
Better predict pharmacokinetic (PK) and drug-drug interactions (DDIs) with DMPK/ADME studies and computational modeling on your compound, prior to clinical trials, to move quickly from discovery to development.
OPPTS 870.7600: Dermal penetration
Physiologically based pharmacokinetics (PBPK) modeling
Compartmental & non-compartmental PK/TK analysis
Screening pharmacokinetics (fast PK)
Bioavailability, bioequivalence and biosimilars modeling
Blood cell partitioning
Microautoradiography techniques
Human pharmacokinetics (PK) prediction
Population pharmacokinetic (PopPK) modeling
Cerebrospinal fluid (CSF) sampling
Quantitative and/or systems pharmacology (QSP/SP) modeling
Enzyme identification (selective inhibitors & recombinant enzymes)
Drug-Drug Interaction (DDI) modeling
Ex vivo enzyme induction for metabolic quality investigation
In vitro cytochrome (CYP) induction
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