Electron Microscopy

Conventional histopathology uses light microscopy to evaluate stained tissue sections on glass slides, however, some objects are too small to distinguish by light microscopy.

Electron microscopy (EM) is a technique used in biomedical research for obtaining high resolution images to investigate ultrastructural details.

GLP TEM Lab Features

In-house automated processors and grid stainers capable of high throughput epoxy resin processing and staining
Resin-embedded sections cut using modern ultramicrotomes
Toluidine blue staining performed for selection of specific structures for analysis by EM, or for neurotoxicity analysis when electron microscopy may not be needed
High quality Transmission Electron Microscopy (TEM) images for review by in house expert TEM pathologists or electronically transferred for client analysis
Good Laboratory Practices (GLP) compliant end-to-end; image capture software has been validated to ensure electronic data regulatory compliance.

When to Include TEM Work

Regulatory advice received e.g. the FDA has alerted to expect changes, such as in the mitochondria, and proactive analysis may speed up the IND process
Cationic amphiphilic drug with known history and reason to suspect phospholipidosis
Biologics—suspect immune complex deposition e.g. kidney glomeruli
Observed abnormal cellular presentation (lesion) e.g. vacuoles, or myelin figures in the neurons of brain tissue

Transmission Electron Microscopy (TEM)

GLP TEM Lab Features

When to Include TEM Work

TEM Posters & Publications

Quick Links

Resources

Labcorp