Modeling & Pharmacometrics

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Pharmacometrics can help to better predict pharmacokinetics (PK), drug response (PD) and drug-drug interactions (DDIs). The ability to predict these aspects of your molecule in development can help you to develop a streamlined program to enable moving quickly from discovery to development. 

In addition, it can also help you build better and more efficient study designs to save time and money.  We can help you in the exploration of how pharmacometrics can lead you to the next stage of your drug development program as well as implement the tools necessary to bring you the results that you need.

Explore Modeling Capabilities

Compartmental PK A compartmental PK model is generally more complex than a noncompartmental PK model and allows for prediction of modeling profiles between compartments when experimental parameters are altered. Compartmental PK is appropriate for large and small molecules. PK / PD Modeling PK / PD modeling creates one set of mathemtical expressions for PK & PD disciplines in order to better understand how a molecule's dose intensity varies over time. As such, PK / PD modeling allows you to better assess ADME properties, establish safety margins and assess dosage change requirements. PK / PD modeling is often used for compartmental PK studies as well as population PK studies. PBPK Modeling PBPK modeling in being accepted more commonly by regulatory agencies as a way to inform clinical study designs and is also used as a way to compare therapeutic indications from multiple drug candidates. PBPK modeling does require a set of in vitro and in vivo data to verify the models. QSP / SP Modeling Quantiative and/or Systems Pharmacology (QSP/SP) modeling, a subdiscipline of pharmacokinetics, is an approach that integrates preclinical mechanistic evidence and physiological system models to investigate and predict drug response.

POSTER
PBPK modeling for optimization of sustained-release orthodontic retainer of Clonidineto

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WEBINAR RECORDING
Understanding FDA regulations & applying in vitro & PBPK modeling techniques

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WEBINAR RECORDING
PBPK modeling to support clinical DDI studies

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Labcorp is a leading global life sciences company that includes contract research and developmental services to the pharmaceutical, medical technology, crop protection and chemical industries.

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