Online Catalog
A collection of nonclinical studies & assays; customization is possible.

Ex vivo enzyme induction for metabolic quality investigation

Evaluation

Metabolism

Ex vivo enzyme induction studies are used to determine whether an administered drug induces or enhances the expression of a drug-metabolizing enzyme. These studies are necessary for ensuring efficacious plasma concentrations of a drug, as increased expression of a drug-metabolizing enzyme can increase the metabolic clearance of the drug, thereby reducing its efficacy and therapeutic effect. They can also be used to understand the reason behind unusual toxicokinetic profiles in safety assessment studies. The studies are conducted in liver microsomes of treated animals that have the closest induction profile to humans such as NHPs, canines, rats or mice.

Models

Canine, NHP, Rat

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About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC. Learn more about our commitment to replacing, reusing and refining nonclinical research models.

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Labcorp is a leading global life sciences company that includes contract research and developmental services to the pharmaceutical, medical technology, crop protection and chemical industries.

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