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Human pharmacokinetics (PK) prediction
Quantitative predictions of PK using in vivo preclinical animal data can estimate systemic exposures for first-in-human studies.
This test can be used to predict human PK, guide first dose choices for a clinical trial, test suitability of the compound for the intended dosage regimen and predict the expected variability in human beings.
Predictions of human PK parameters include the clearance, volume of distribution, half-life, bioavailability, effective dose and dosage regimen, plasma concentration time profile, inter-individual variability and drug-drug interaction.
