Online Catalog
A collection of nonclinical studies & assays; customization is possible.

Cerebrospinal fluid (CSF) sampling

Analysis

Metabolism

Cerebrospinal fluid (CSF) concentrations can be used as a surrogate measure of the central nervous system's (CNS) availability of drugs. 

Systemically administered drugs can reach CSF either directly via passage across the choroid plexus or indirectly by passage across the blood-brain barrier (BBB), followed by diffusion/convection transport from the interstitial fluid (ISF) to CSF. 

CSF penetration in research model studies are used for assessment of a CNS drug delivery in early preclinical drug development. To perform a full pharmacokinetic (PK) profile of a compound in CNS, multiple CSF sampling time points are needed.

Cannulated and direct stick (rodent, canine, NHP) models are available, as are capabilities for serial survival sampling and colony utilization.

Models

Canine, Mouse, NHP, Rat

Request a Quote

About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC. Learn more about our commitment to replacing, reusing and refining nonclinical research models.

Labcorp logo

Labcorp is a leading global life sciences company that includes contract research and developmental services to the pharmaceutical, medical technology, crop protection and chemical industries.

Navigation
Scroll to top