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A collection of nonclinical studies & assays; customization is possible.

OECD 431: In vitro skin corrosion (3D model)

Study

Toxicology, In Vitro Alternate

The OECD 431: In vitro Skin Corrosion 3D-Model Test guideline assesses the potential of an agent to cause skin corrosion. The test agent is applied to the 3D model, which consists of a reconstructed epidermis with a functional stratum corneum to mimic human skin, and cell viability assessed. The principle behind the test is that corrosive substances can infiltrate the cell and, as they are cytotoxic to the underlying layers, will reduce cell viability below a certain threshold. This allows identification and classification of corrosive substances, which is essential to ensure safe handling, packing and transportation of chemicals, pesticides and cosmetics that have the potential to cause skin tissue damage.

Industry Market

Chemical, Crop, Device, Pharma

Phase

Nonclinical

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About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC. Learn more about our commitment to replacing, reusing and refining nonclinical research models.

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Labcorp is a leading global life sciences company that includes contract research and developmental services to the pharmaceutical, medical technology, crop protection and chemical industries.

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