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Eye irritation
Eye irritation is defined as the production of changes in the eye following the application of a test substance to the anterior surface of the eye. These changes are fully reversible within 21 days of application (UNECE, Part 3.3, 2015). It is a key toxicological endpoint required to achieve fundamental product safety standards and to guide therapy development. There are various eye irritation test models; one example is in vitro bovine corneal opacity and permeability (BCOP) assays. These can be used to screen substances early on in development or during GLP toxicity testing.
