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A collection of nonclinical studies & assays; customization is possible.

OECD 456: H295R Steroidogenesis assay

Study

Toxicology, Endocrine, In Vitro Alternate

This assay provides an in vitro screen for identifying substances that interfere with steroidogenesis, specifically, production of 17ß-estradiol and testosterone and is suitable for Level 2 endocrine disruption testing. 

The human H295R adreno-carcinoma cell line used for the assay expresses genes that encode for all the key enzymes for steroidogenesis. Following exposure to a range of concentrations of the test substrate, concentrations of hormones in the cell medium are measured and compared with fixed concentrations of a known inducer and inhibitor of hormone production.

View more cell lines. 

Industry Market

Chemical, Crop, Pharma

Phase

Nonclinical

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Labcorp is a leading global life sciences company that includes contract research and developmental services to the pharmaceutical, medical technology, crop protection and chemical industries.

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