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Model of Invasive Aspergillosis in Immunocompromised Mice
Aspergillus is a common filamentus fungi and infection can result in three main types of bronchopulmonary aspergillosis; invasive aspergillosis, chronic aspergillosis, and allergic aspergillosis. Invasive aspergillosis affects severely immunocompromised patients and can lead to nearly 100 % mortality if left untreated.
Mice undergo an immunosuppression regimen and are administered fungi suspended in saline; model length can be manipulated by adjustment of the initial fungal load. At termination fungal load can be confirmed using the clinically relevant surrogate biomarker Galactomannan.
| Study Design | |
|---|---|
| Species/Strain | C57BL/6J mouse |
| Model | Invasive aspergillosis in immunocompromised mice |
| Relevant Use | Efficacy of novel antifungals |
| Readouts Available | Daily Bodyweights and Clinical Signs, fungal load, BAL differential cell counts, BAL cytokines and Pathology (H&E and PAS). |
Study data generated by Labcorp Huntingdon Pharmacology.
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