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Bronchoconstriction models for LABA, LAMA & MABAs
This model allows for the assessment of bronchoprotective effects of novel bronchodilators to agonist challenge (Methacholine and or Histamine) induced bronchoconstriction in the anaesthetised guinea-pig.
Formoterol demonstrated significant inhibition on resistance and compliance of airway induced by histamine and methacholine in anaesthetised guinea pig.
Formoterol also showed significant bronchoprotection against 5µg/kg histamine and methacholine challenge.
| Study Design | |
|---|---|
| Species/Strain | Dunkin Hartly Guinea Pig |
| Model | Airway Bronchoconstriction |
| Relevant Use | Screening and assessing the efficacy of new candidate LABA, LAMA and MABA's |
| Readouts Available | Invasive Lung Function (terminal) assessment of AHR (airway hyper responsiveness) using the Flexivent system |
Study data generated by Labcorp Huntingdon Pharmacology.
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