Chlorine Induced Lung Injury

Discovery

Chlorine Gas Injury can lead to epithelial injury, airway remodelling and potentially ARDS. Inhalation models of chlorine toxicity provide unique opportunities for testing potential pharmacologic rescue agents.

Labcorp’s chlorine exposure model has demonstrated significant increases in tidal volume, penh and lower respiratory rates, lung odema, increases in BAL IL-1β, MIP-1α, MCP-1 and clinical signs.

Study Design
Species/Strain	SD rat
Model	Chlorine Induced Lung Injury
Relevant Use	Assessing the efficacy of novel compounds targeted at chemical lung injury
Readouts Available	Clinical signs, bodyweight, Lung function (WBP and invasive), lung oedema, BAL differential cell counts, and BAL cytokines, histopathology

Study data generated by Labcorp Huntingdon Pharmacology.

Molecule or Product Type

Biologics, Small Molecule

Models

Rat

Administration Routes

Dermal, Dietary, Gavage, Implant, Infusion, Inhalation, Intracranial, Intracutaneous, Intramuscular, Intranasal, Intraperitoneal, Intrathecal, Intratracheal, Intravenous, Ocular, Rectal, Subcutaneous, Transcortical, Vaginal

Regulatory

IND & CTA, NDA & BLA, Post-Market

Industry Market

Pharma

Phase

Discovery, Nonclinical

Related Models

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