COPD: LPS neutrophil chemotaxis model (systemic)

Discovery

A key hallmark of Sepsis is systemic inflammation.

Validated positive control is the oral steroid Dexamethasone.

Systemic data generated in the rat and Systemic data generated in the mouse.

Study Design
Species/Strain	SD rat, Balb/c mouse
Model	Systemic LPS neutrophil chemotaxis model
Relevant Use	Screening new candidate drugs for the reduction of systemic inflammation
Readouts Available	Systemic cytokines

Study data generated by Labcorp Huntingdon Pharmacology.

Molecule or Product Type

Biologics, Small Molecule

Models

Mouse, Rat

Administration Routes

Dermal, Dietary, Gavage, Implant, Infusion, Inhalation, Intracranial, Intracutaneous, Intramuscular, Intranasal, Intraperitoneal, Intrathecal, Intratracheal, Intravenous, Ocular, Rectal, Subcutaneous, Transcortical, Vaginal

Regulatory

IND & CTA, NDA & BLA, Post-Market

Industry Market

Pharma

Phase

Discovery, Nonclinical

Related Models

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