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A collection of nonclinical studies & assays; customization is possible.

ToxTracker® assay

Assay

Toxicology, Genetic

The ToxTracker® reporter assay consists of a panel of six mouse embryonic stem cell lines that are modified with different green fluorescent protein (GFP) tagged reporters for various cellular signaling pathways involved in carcinogenesis. 

The assay can be used to monitor the activation of signaling pathways associated with DNA damage, oxidative stress, general p53-dependent cellular stress as well as protein unfolding response, thereby providing insight into the mechanisms of (geno)toxicity, of the test compound. 

The ToxTracker reporter cell lines are combined in 96-well plates, exposed to the test samples, typically for 24h and induction of the fluorescent reporters is examined by flow cytometry.

Models

Mouse

Industry Market

Chemical, Crop, Pharma

Phase

Discovery, Nonclinical

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About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC. Learn more about our commitment to replacing, reusing and refining nonclinical research models.

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Labcorp is a leading global life sciences company that includes contract research and developmental services to the pharmaceutical, medical technology, crop protection and chemical industries.

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