Carcinogenicity studies

Study

Toxicology, Carcinogenicity

Carcinogenicity studies are typically required for therapies expected to run continuously for at least six months (or intermittently for chronic or recurrent conditions).

Animals are observed for development of neoplastic lesions when exposed to the test therapy to evaluate the relevant risk in humans. Duration of carcinogenicity studies in transgenic or knockout mice models, for example, is determined by the kinetics of oncogenesis in the animal model being used in the bioassay. Toxicology and carcinogenicity studies can also be combined.

Models

Mouse, Rat

Administration Routes

Dermal, Dietary, Gavage, Intramuscular, Intravenous, Subcutaneous, Vaginal

Regulatory

IND & CTA

Industry Market

Pharma

Phase

Clinical, Nonclinical

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About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC. Learn more about our commitment to replacing, reusing and refining nonclinical research models.