Bone implants / healing (tibia, sternum) for small research models
Bone implants/healing (tibia, sternum) for small research models investigate biological microenvironment responses produced by microroughness of implant surfaces on the bone. For example, the proximal tibial epiphysis in rabbit models are selected for titanium plate-like device insertion. Surface topography of the implant is key to new bone formation; smooth surfaces integrate through appositional bone growth while microrough surfaces may facilitate bone growth directly to the implant surface, a contact osteogenesis pattern.