Online Catalog
A collection of nonclinical studies & assays; customization is possible.

Muscle circumference (anabolic effects)

Evaluation

Toxicology, Specialty

Muscle circumference (anabolic effects) can be measured to research MYO-029 exposure. Suppression of myostatin (GDF-8) is a vital pathway for muscle-wasting disorders. Studies with NHPs where therapies target myostatin, e.g., MYO-029 (an antimyostatin monoclonal antibody), circumferences are recorded of various muscles – biceps, quadriceps and gastrocnemius. Based on pharmacokinetic (PK)/pharmacodynamic (PD) relationships, the data can be used to determine clinical efficacy in patients with muscular dystrophy.

Models

NHP

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About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC. Learn more about our commitment to replacing, reusing and refining nonclinical research models.

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Labcorp is a leading global life sciences company that includes contract research and developmental services to the pharmaceutical, medical technology, crop protection and chemical industries.

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