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A collection of nonclinical studies & assays; customization is possible.

Pyloric ligation procedure

Surgical Procedure

Toxicology, Specialty

Pyloric ligations induce accumulation of acid and pepsin, which leads to autodigestion of gastric mucosa and ulceration. Some studies administer pentagastrin or histamine dihydrochloride subcutaneously. 

After the stomach content is collected, the volume of gastric juice is recorded and the concentration of free acid can be calculated and analyzed.

Models

Rat

Industry Market

Pharma

Phase

Nonclinical

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About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC. Learn more about our commitment to replacing, reusing and refining nonclinical research models.

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Labcorp is a leading global life sciences company that includes contract research and developmental services to the pharmaceutical, medical technology, crop protection and chemical industries.

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