Online Catalog
A collection of nonclinical studies & assays; customization is possible.

Metabolic stability assays

Evaluation

Metabolism

Studies measure compound half-life, calculate intrinsic clearance and predict human pharmacokinetic (PK) profiles in anticipation of first-in-human (FIH) trials. 

Disappearance of a parent compound or the appearance of metabolites is measured following incubation with hepatocytes, liver microsomes or plasma, enabling calculations of half-life and intrinsic clearance.

Biotransformation of test article and metabolite profiles can then be elucidated.

 

Molecule or Product Type

Biologics, Small Molecule

Regulatory

IND & CTA

Industry Market

Pharma

Phase

Nonclinical

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About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC. Learn more about our commitment to replacing, reusing and refining nonclinical research models.

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Labcorp is a leading global life sciences company that includes contract research and developmental services to the pharmaceutical, medical technology, crop protection and chemical industries.

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