Online Catalog
A collection of nonclinical studies & assays; customization is possible.

Laminectomy: Lumbar (intrathecal)

Surgical Procedure

Drug concentrations in cerebrospinal fluid (CSF) are typically used as a surrogate measure of their availability in the central nervous system (CNS). In animal studies, CSF penetration studies is used for assessment of CNS drug delivery in early preclinical drug development. 

The protocol involves hemilaminectomy of the 4th vertebra to expose the spinal cord and catheterization of the intrathecal space. Ten collections/day at 0.2-0.3ml based on protocol design and duration between collections.

The procedure can provide access for CSF collection for up to 1 year.

Models

NHP

Industry Market

Pharma

Phase

Nonclinical

Request a Quote

About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC. Learn more about our commitment to replacing, reusing and refining nonclinical research models.

Labcorp logo

Labcorp is a leading global life sciences company that includes contract research and developmental services to the pharmaceutical, medical technology, crop protection and chemical industries.

Navigation
Scroll to top