Biomarker method development & analysis (preclinical & clinical)

Assay

Toxicology, Immunotoxicology, Bioanalysis

Biomarker assay development and method validation is a complex process that depends on a number of parameters including choice of matrix, sample integrity, and assay standardization and accuracy.

Preclinical biomarker method development & analysis

Biomarker detection methodology for use on a preclinical study. Can develop assays for a variety of research models, utilizing numerous assay platforms as described below.

Clinical biomarker method development & analysis

Multiple measurement modalities for semi-quantitative and qualitative analyses of multiple biomarkers in a variety of biological matrices. Performed on human samples.

Technology & platforms

Luminex: Fluorescent method for the quantification of multiple biomarkers in a variety of biological matrices. Allows for the quantification of the most biomarkers per sample of all biomarker detection methodologies.
MSD: Chemiluminescent method to quantify multiple biomarkers in a variety of biological matrices. Greatest dynamic range of all biomarker detection methodologies and greatest sensitivity.
ELISA: Colorimetric method to quantify individual biomarkers in a variety of biological matrices.

Also see biomarker development & validation during the discovery phase.

Molecule or Product Type

Biomarkers

Models

Canine, Human, Mouse, NHP, Rat

Industry Market

Pharma

Phase

Clinical, Nonclinical

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About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC. Learn more about our commitment to replacing, reusing and refining nonclinical research models.